Analyze protein sequences and structure

full_protein_analysisskillsetup L3147
InternScience/scp
What it does

Analyze protein structures, interactions, and functional domains from sequences or PDB files

Best for

Rapidly characterizes unknown proteins by identifying homologs, domains, and predicted 3D structure.

Inputs
  • · [object Object]
  • · [object Object]
  • · [object Object]
Outputs
  • · [object Object]
  • · [object Object]
  • · [object Object]
Requires
  • · BLAST
  • · InterProScan
  • · Pymol
  • · DSSP
  • · FoldSeek
Preconditions

FASTA or PDB file, reference database access

Failure modes

Sequence too short for reliable homology; PDB missing cofactors affects structure interpretation

Trust signals
  • · BLAST E-value statistics
  • · Pfam domain confidence scores
  • · Structure validation (Ramachandran)