Find and map DNA regulatory elements

Annotate genomic regions with regulatory function predictions

Linking noncoding variants or peaks to biological function without training custom classification models.

• · Genomic coordinates (BED)
• · Chromatin accessibility data (ATAC-seq, DNase)

• · Regulatory element classification (promoter, enhancer, silencer)
• · TF binding predictions

• · ENCODE blacklist
• · JASPAR
• · FIMO
• · chromVAR

• · Reference genome
• · Chromatin data (optional)

• · Enhancer-gene assignment ambiguous (shadow enhancers)
• · TF motif false positives high

• · ENCODE regulatory standards
• · JASPAR motif database
• · Multi-modality integration