cyberneticlibrary

Connect GWAS disease variants to regulatory elements

gwas-catalogskillsetup L235
ammawla/encode-toolkit
What it does

Query NHGRI GWAS Catalog for trait-variant associations

Best for

Finding GWAS variants that overlap ENCODE regulatory elements to identify disease-associated regulatory effects

Inputs
  • · SNP rs ID
  • · trait name
  • · p-value threshold
Outputs
  • · GWAS variants
  • · effect sizes
  • · pubmed references
Requires
  • · GWAS Catalog REST API
  • · NHGRI public database
Preconditions

None; open access

Failure modes
  • · Trait name ambiguity
  • · Multiple hits with low p-values
  • · Effect size heterogeneity across studies
Trust signals
  • · NHGRI official repository
  • · Curated variant-trait associations