cyberneticlibrary

Cross-reference NCBI GEO with ENCODE experiments

geo-connectorskillsetup L235
ammawla/encode-toolkit
What it does

Query and cross-reference NCBI GEO with ENCODE datasets

Best for

Finding complementary expression datasets in GEO that validate or extend ENCODE regulatory findings

Inputs
  • · ENCODE experiment accession
  • · GEO accession (GSE/GSM)
  • · search term
Outputs
  • · GEO metadata
  • · complementary datasets
  • · series matrices
Requires
  • · NCBI E-utilities API
  • · GEO acc.cgi endpoint
  • · FTP GEO
  • · SRA
Preconditions

NCBI email/API key for rate limiting (optional, 3 req/sec without)

Failure modes
  • · API rate limiting on large batch queries
  • · Missing GEO cross-references in ENCODE
  • · SOFT format parsing complexity
Trust signals
  • · NCBI official E-utilities documented
  • · Detailed GEO entity hierarchy
  • · Real query examples