cyberneticlibrary

Process molecular biology sequences programmatically

biopythonskillsetup L227,559
K-Dense-AI/scientific-agent-skills
What it does

Manipulate sequences and access NCBI

Best for

When writing batch molecular biology pipelines that manipulate sequences, parse multiple file formats, and access NCBI programmatically.

Inputs
  • · Sequence files (FASTA, GenBank)
  • · NCBI query terms
Outputs
  • · Parsed sequence records
  • · Alignment results
  • · NCBI metadata
Requires
  • · NCBI Entrez
  • · BLAST
Preconditions
  • · Python 3.10+
  • · Biopython 1.87+ installed
  • · NCBI email set (Entrez queries)
Failure modes
  • · NCBI rate limit (3 req/s) causes intermittent failures
  • · GenBank file format ambiguity in legacy sequences
Trust signals
  • · Biopython 1.87 (current, CVE-2025-68463 fixed)